RESEARCH

fNIRS

Near-Infrared Spectroscopy (NIRS)

Neuronal activity is known to be associated with then changes in the blood oxygenation and deoxygenation due to functional brain activities. These changes are referred to cerebral hemodynamics. The difference in the near-infrared absorption spectra of oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) enables the concentrations of the two molecules to be separately identified. NIRS employs wavelengths of 600 to 900 nm, which experience very low levels of absorption in tissues, allowing deeper penetration into a brain tissue.

AI based NIRS signal processing

Conventional modeling method used for analyzing the brain property through NIRS has some limitations. Since human brain is complex system to investigate, there are difficulties to produce accurate mathematical model. To overcome this problem, several ideas from deep-learning are actively introduced. Extracted results from trained neural network regressor show better performance than conventional modeling.

Portable NIRS system using IC technology

Conventional devices were not suitable for daily diagnosis or cognitive task monitoring due to their bulky size. To solve this problem, we can make the system portable. IC technology is a strong tool for miniaturizing a system while maintaining or even enhancing the overall system performance. Based on our research group¡¯s understanding on IC design, we were able to create a portable NIRS system (NIRSIT). Further research is conducted to improve hardware functionalities. We are always looking for better ideas to apply in our system.





Publication List

Clinical Study


Tae Jung Kim, Jaemyoung Kim, Ji Sung Lee, Soo-Hyun Park, Hae-Bong Jeong, Jongkwan Choi, Kyuseok Kim, Hyeon-Min Bae, Sang-Bae Ko, ¡°Prognostication of neurological outcome after cardiac arrest using wavelet phase coherence analysis of cerebral oxygen¡±, Resuscitation, March 2020.


Jaemyoung Kim, Jongkwan Choi, Mingyu Choi, Minsu Ji, Gunpil Hwang, Sang-Bae Ko, Hyeon-Min Bae, ¡°Assessment of cerebral autoregulation using continuous-wave near-infrared spectroscopy during squat-stand maneuvers in subjects with symptoms of orthostatic intolerance¡±, Scientific Reports, no. 8, Sept. 2018.

Mingyu Choi, Jaemyoung Kim, Minsu Ji, Haeil Lee, SeongKwon Yu, Hyeon-Min Bae, ¡°Dimension reduction method for fast diffuse optical tomography¡±, SPIE Photonics Europe, April 2018.

Jaemyoung Kim, He-Won Jung, SeongKwon Yu, Mua Kim, Jongkwan Choi, Mingyu Choi, Gunpil Hwang, Minsu Ji, Kyu-Seok Kim, Sang-Bae Ko, Hyeon-Min Bae, ¡°Assessment of cerebral autoregulation using near infrared spectroscopy during squatstand maneuvers in healthy subjects with experiencing frequent symptoms of orthostatic hypotension¡±, BRAIN & BRAIN PET 2017 (ISCBFM) Journal of Cerebral Blood Flow & Metabolism, no. 37, pp. 428, April 2017. - Early Career Investigator Travel Bursary Award 

Device

Gunpil Hwang, Jongkwan Choi, Jaehyeok Yang, Sungmin Lim, Jaemyoung Kim, Mingyu Choi, Dae-Shik Kim, Kiuk Gwak, Jinwoo Jeon, Hee Sup Shin, Il-Hwan Choi, Sol Park, Hyeon-Min Bae, ¡°A 2.048 Mb/s Full-Duplex Free-Space Optical Transceiver IC for a Real-Time In Vivo Neurofeedback Mouse Experiment Under Social Interaction¡±, IEEE Symposium on VLSI Circuits, pp. C262-263, June 2016.

Jongkwan Choi, Jaemyoung Kim, Gunpil Hwang, Jaehyeok Yang, Mingyu Choi, Hyeon-Min Bae, ¡°Time-Divided Spread-Spectrum Code-Based 400 fW-Detectable Multichannel fNIRS IC for Portable Functional Brain Imaging¡±, IEEE Journal of Solid-State Circuits, no. 2, pp. 484-495, Feb. 2016.

Jongkwan Choi, Jaemyoung Kim, Gunpil Hwang, Jaehyeok Yang, Mingyu Choi, Hyeon-Min Bae, ¡°A Time-Divided Spread-Spectrum Code Based 15pW- Detectable Multi-Channel fNIRS IC for Portable Functional Brain Imaging¡±, IEEE International Solid-State Circuits Conference 2015, pp. 1-3, Feb. 2015.

Jongkwan Choi, Mingyu Choi, Jaemyoung Kim, Hyeon-Min Bae, ¡°Efficient Data Extraction Method for Near Infrared Spectroscopy (NIRS) Systems with High Spatial and Temporal Resolution¡±, IEEE Transactions on Biomedical Circuits and Systems, no. 2, pp. 169 - 177, April 2013. - Invited Paper